High surface coverage and exhaustive double end-capping
An excellent choice for general purpose C18 columns
Excellent peak shapes for acids, bases and neutrals
High performance over a wide pH range (pH 1.5 – 10.0)
Best performance for separation of highly basic compounds, ideally for pharmaceutical compounds
Available in dimensions from analytical to preparative for all sample sizes
UltisilTM XB-C18 columns,featuring high surface coverage and exhaustive end-capping, are an excellent choice as a general-purpose C18 column for a wide variety of organic compounds.The bonding chemistry is optimized specifically for our base material.Our proprietary double end-capping leads to optimal performance with neutral, polar, acidic, basic, and chelating compounds.The phase, when used in mid pH, shows the biggest advantage of symmetric peaks for highly basic compounds, which normally show peak tailing on other conventional C18 columns.The high surface coverage and exhaustive end-capping make columns suitable over a wide pH range of pH 1.5 to 10.0 with enhanced stability.
Analysis of Acids:UltisilTM XB-C18 phase also provides excellent performance for organic acids.Figure 2 shows the application of separation of series of organic acids with good peak shapes.
Analysis of Strong Bases at Middle pH: The analysis of strong basic compounds at middle pH provides a further evaluation of the quality of C18 phase because strong basic compounds such as tricyclic antidepressants (TCAs) are notorious for poor peak shapes and irreversible adsorption on traditional C18 packings.The separation of TCAs at pH 7.0 can be used to clearly distinguish the difference of quality of the columns from manufacturers.Figure 3 shows the chromatogram of separation of TCAs at pH 7.0.UltisilTM XB-C18 column provides the best peak shape and resolution of these antidepressants.The high surface coverage and minimal ion and uniform ion exchange sites of the surface contribute to the excellent peak shape and chromatographic performance.
Figure 2: Separation of Organic Acids
Figure 3: Separation of tricyclic antidepressants (TCAs) at pH 7.0